Table 1.
Resistance values determined by clonogenic assay expressed as IC50for each cell line and drug(s)
| Resistant line | IC50of resistant line to either CBN and/or DXL | IC50of co-cultured control to either CBN and/or DXL | Fold resistance. Ratio of IC50of resistant line/ co-cultured control |
|---|---|---|---|
| A2780CBN |
7.77 x 10-5 M CBN |
5.73 x 10-6 M CBN |
13.56 |
| |
3.62 x 10-10 M DXL |
5.76 x 10-10 M DXL |
0.63 |
| A2780DXL |
3.61 x 10-7 M DXL |
8.91 x 10-11 M DXL |
4051.63 |
| |
2.20 x 10-6 M CBN |
6.75 x 10-6 M CBN |
0.33 |
| A2780CBNDXL |
8.02 x 10-6 M CBN |
6.37 x 10-7 M CBN |
12.59 |
| |
8.02 x 10-9 M DXL |
6.37 x 10-10 M DXL |
|
| A2780CBNDXL |
2.52 x 10-5 M CBN |
2.50 x 10-6 M CBN |
10.08 |
| A2780CBNDXL | 1.47 x 10-8 M DXL | 1.84 x 10-9 M DXL | 7.99 |