Table 3.
Validation gene set, genes present in all three cell lines according to microarray analysis
| Gene designation | Protein name | General function | Cell line | Fold change | P value for fold change | Fluorescence value resistant line | Fluorescence value parent line |
|---|---|---|---|---|---|---|---|
|
LAYN |
Layilin |
Binds hyaluronan, may play a role in cell adhesion and motility |
A2780CBN |
−154.83 |
5.63 x 10-4 |
88.25 |
13106.25 |
| |
|
|
A2780DXL |
−12.95 |
4.64 x 10-10 |
75.00 |
948.50 |
| |
|
|
A2780CBNDXL |
−145.93 |
8.16 x 10-4 |
151.75 |
14364.25 |
|
PRSS7 |
TMPRSS15, Transmembrane protease, serine 15/enterokinase |
Membrane bound enterokinase |
A2780CBN |
164.34 |
9.35 x 10-3 |
1927.75 |
15.50 |
| |
|
|
A2780DXL |
84.44 |
2.24 x 10-8 |
3028.75 |
37.63 |
| A2780CBNDXL | 123.06 | 1.79 x 10-3 | 6559.00 | 60.00 |