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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: Biochim Biophys Acta. 2012 Sep 12;1830(2):2435–2448. doi: 10.1016/j.bbagen.2012.09.002

Figure 1. Regulation of Adult Neurogenesis in the Dentate Gyrus of the Hippocampus and the Subventricular Zone of the Lateral Ventricle.

Figure 1

Figure 1

Shown is a schematic diagram illustrating the sequential steps underlying the process of neurogenesis in the adult hippocampus (1A) and the subventricular zone (1B). Figure 1A shows the transition from a radial-like glia cell to neural progenitor cell in the adult SGZ, as well as subsequent stages of neuronal differentiation, maturation and migration. Figure 1B illustrates self-renewal and differentiation of SVZ NSCs and subsequent maturation and migration along the RMS. The expression of cell-specific markers during the various stages of development is shown. The actions of major molecular regulators as well as crosstalk between various molecular players during various stages of adult hippocampal (1A) and subventricular zone (1B) neurogenesis are also presented. GCL, granule cell layer; ML, molecular layer; OB, olfactory bulb; RMS, rostral migratory stream; SGZ, subgranular zone; SVZ, subventricular zone.