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. Author manuscript; available in PMC: 2014 Jan 9.
Published in final edited form as: Nano Lett. 2012 Dec 20;13(1):153–158. doi: 10.1021/nl3037068

Figure 3.

Figure 3

(a) Schematic for a PTP activity assay using a NW-cell sandwich assembly. (b-d) MALDI-TOF spectra for: (b) substrate peptides cleaved by TEV; (c) peptides cleaved from NWs by TEV after an hour of sandwich assembly with immobilized HeLa cells; and, (d) peptides cleaved by TEV after an hour-long sandwich assay with the inclusion of the PTP inhibitors, α-bromo-4-hydroxyacetophenone (80 μM) and sodium orthovanadate (200 μM). Substrate and product peptides show three distinct mass peaks including two adducts (Na+ and K+), respectively.