Table 2.
Brain region | Brodmann area | Area (mm2) | Mean, t-value | Mean, P-value | Peak, t-value | Peak, P-value | Talairach coordinates of peak vertex |
---|---|---|---|---|---|---|---|
Left hemisphere | |||||||
Middle/inferior temporal cortexa | 20/38 | 3770.050 | 3.672 | <0.001 | 7.130 | <0.001 | −43, −4, −33 |
Superior frontal cortex/OFCa | 10/47 | 1041.020 | 2.654 | 0.010 | 3.663 | <0.001 | −22, 55, −5 |
Fusiform cortex | 37 | 902.250 | 2.520 | 0.014 | 3.404 | 0.001 | −30, −59, −13 |
Ventromedial PFC/OFC | 11 | 643.150 | 2.317 | 0.023 | 3.138 | 0.002 | −20, 10, −12 |
Middle frontal cortex | 10 | 563.790 | 2.370 | 0.020 | 3.072 | 0.003 | −39, 43, 12 |
Postcentral cortexa | 5 | 472.820 | −2.570 | 0.012 | −3.885 | <0.001 | −14, −47, 68 |
Posterior cingulate cortex | 31 | 411.460 | −2.431 | 0.017 | −3.026 | 0.003 | −10, −48, 27 |
Angular gyrus | 39 | 387.460 | −2.177 | 0.032 | −2.418 | 0.018 | −37, −75, 27 |
Cuneus cortex | 17 | 374.280 | −2.426 | 0.017 | −3.127 | 0.002 | −5, −74, 10 |
PFC | 10 | 239.180 | 2.345 | 0.021 | 2.927 | 0.004 | −4, 60, 12 |
Superior frontal cortex | 6 | 215.900 | 2.350 | 0.021 | 2.771 | 0.007 | −25, −6, 60 |
Intraparietal cortexa | 7 | 214.070 | −2.719 | 0.008 | −3.627 | 0.001 | −20, −62, 28 |
Right hemisphere | |||||||
Middle/inferior temporal cortexa | 1/38 | 2483.600 | 3.468 | 0.001 | 6.336 | <0.001 | 35, 3, −35 |
Inferior parietal cortex/ postcentral cortexa | 40/3 | 2001.300 | −2.753 | 0.007 | −4.620 | <0.001 | 35, −52, 34 |
Ventromedial PFC/OFCa | 11 | 1910.640 | 2.689 | 0.009 | 4.976 | <0.001 | 17, 31, −15 |
Middle occipital/temporal cortexa | 19/39 | 1038.670 | −2.784 | 0.007 | −4.030 | <0.001 | 46, −64, 26 |
Supramarginal gyrusa | 40 | 423.600 | −2.871 | 0.005 | −3.941 | <0.001 | 51, −25, 27 |
Superior frontal cortexa | 6 | 380.630 | 2.919 | 0.005 | 4.117 | <0.001 | 14, −6, 64 |
Superior frontal cortex | 8 | 234.490 | 2.560 | 0.012 | 3.310 | 0.001 | 22, 11, 42 |
OFC, orbitofrontal cortex; PFC, prefrontal cortex. The brain regions in bold indicate areas showing significantly increased cortical thickness in meditation practitioners compared to controls. The statistical results were corrected for multiple comparisons using a Monte-Carlo simulation (corrected P < 0.01; |t| > 1.97, N > 214).
aThe regions that are significant under a corrected threshold of FDR q < 0.05 (please refer to Supplementary Figure S4)