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. 2012 Jul;93(Pt 7):1432–1441. doi: 10.1099/vir.0.042176-0

Fig. 3.

Fig. 3.

Low-dose inoculation of MNV-3 results in establishment of viral persistence. C57BL/6 mice 4–5 weeks of age were inoculated with 100 µl sample containing 104, 103, 102 or 10 TCID50 MNV-3, 105 TCID50 UV-inactivated MNV-3, or filtered cell-culture lysate (Mock). (a) Animals infected with 10 or 104 TCID50 MNV-3 showed detectable viral RNA in faeces by day 28 post-infection. Animals infected with 102 or 103 TCID50 were also positive (not included in the figure). Animals mock-inoculated with UV-inactivated MNV-3 or cell-culture lysate presented no detectable viral RNA. (b) Viral RNA levels in faeces collected at 28 days post-infection from animals mock-infected (▪) or infected with 10 (◊), 104 (□) or 105 (○) TCID50 MNV-3 (from Fig. 2). (c) Titration by TCID50 in RAW264.7 cells of infectious virus isolated from faecal samples of animals shown in (b). Horizontal bars in (b) and (c) represent mean values.