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. 2012 Jul;93(Pt 7):1432–1441. doi: 10.1099/vir.0.042176-0

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© 2012 SGM

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 4. — MNV-3 shows fast kinetics of replication in mice. Groups of six mice were infected with a low dose of MNV-3 [10 (•) or 10² (□) TCID₅₀] and secretion of virus was monitored at days 1, 2, 3, 7 and 28 post-infection. MNV-3 shows fast replication kinetics, reaching maximum levels of RNA molecules in stools by day 2 post-infection. Establishment of infection is dose-dependent, with three of six animals inoculated with 10² TCID₅₀, and only one of six animals inoculated with 10 TCID₅₀, being positive for virus shedding at 1 day post-inoculation. Horizontal bars represent mean values.