Table 5.

Reclassification of Participants for the 10-Year Risk Prediction of Cardiovascular Disease Corresponding to the Framingham Risk Score and After Adding Serum Peroxiredoxin 4^*

	Framingham Risk Score With Prx4
Framingham Risk Category	Low Risk	Intermediate Risk	High Risk	Reclassification (%)
In participants without outcome
Low risk	4647	38	0	1.0
Intermediate risk	207	1984	81	13.0
High risk	0	23	494	4.0
In participants with outcome
Low risk	104	2	0	2.0
Intermediate risk	9	299	24	10.0
High risk	0	9	213	4.0
Total sample
Low risk	4751	40	0	1.0
Intermediate risk	216	2283	105	12.0
High risk	0	32	707	4.0

^*Corresponding to the Framingham risk score and after adding serum peroxiredoxin 4, low risk denotes <6%, intermediate risk 6% to 20%, and high risk >20% for the 10-year of cardiovascular disease. Net reclassification index was 2.7 (95% CI 0.7 to 4.7; P=0.01), and integrated discrimination improvement was 0.0032 (95% CI 0.0014 to 0.0049; P<0.001).