Table 2.
Baseline Antihyperglycemic and Cardioprotective Medications of Study Population
| Variable | Bromocriptine-QR (N=2054) | Placebo (N=1016) |
|---|---|---|
| Diabetes treatment, n (%) | ||
| Diet only | 257 (12.5) | 114 (11) |
| One oral hypoglycemic agent | 806 (39) | 403 (40) |
| Two oral hypoglycemic agents | 686 (33) | 323 (32) |
| Oral agent plus insulin | 171 (8) | 98 (10) |
| Insulin only | 133 (6) | 78 (8) |
| Not reported | 1 | 0 |
| Antidiabetes medications by agent, n (%) | ||
| Metformin | 1209 (59) | 581 (57) |
| Rosiglitazone | 233 (11) | 111 (11) |
| Pioglitazone | 161 (8) | 83 (8) |
| Sulfonylurea/glinide | 759 (37) | 392 (39) |
| Other | 29 (1) | 19 (2) |
| Cardioprotective medications by class, n (%) | ||
| ACE inhibitors | 994 (48) | 477 (47) |
| Angiotensin II receptor inhibitors | 271 (13) | 135 (13) |
| β-Blockers | 452 (22) | 247 (24) |
| Diuretics, thiazide | 445 (22) | 233 (23) |
| Sulfamides, loop diuretics | 166 (8) | 89 (9) |
| Other diuretic* | 75 (4) | 49 (5) |
| Calcium channel blockers† | 362 (18) | 202 (20) |
| Hmg CoA reductase inhibitor | 1165 (57) | 594 (58) |
| Fibrate | 157 (8) | 78 (8) |
| Platelet aggregation inhibitors | 943 (46) | 500 (49) |
| Cardioprotective medications by number, n (%) | ||
| Taking 1 cardioprotective agent | 376 (18) | 184 (18) |
| Taking 2 cardioprotective agents | 411 (20) | 224 (22) |
| Taking 3 cardioprotective agents | 390 (19) | 183 (18) |
| Taking ≥4 cardioprotective agents | 678(33) | 345 (34) |
*
Other diuretics include aldosterone inhibitors, low-ceiling diuretics.
†
Calcium channel blockers include dihydropyridine, phenylalkylamine, benzothiazepine.