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. 2012 Oct 25;1(5):e002360. doi: 10.1161/JAHA.112.002360

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© 2012 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley-Blackwell.

This is an Open Access article under the terms of the Creative Commons Attribution Noncommercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Figure 5. — Administration of the ASK1 inhibitor (GS-459679, 30 mg/kg) with a delay at reperfusion led to a time-dependent loss of effect on infarct size (top panels) and regional wall motion abnormalities (bottom left panel), whereas global LV systolic function also was preserved with a 30-min delay (bottom right panel). *P<0.001 vs sham; †P<0.001 vs vehicle-treated AMI; ‡P<0.001 vs no delay. n=4 to 6 per group. AMI indicates acute myocardial infarction; LV, left ventricle; WMSI, wall motion score index; and LVEF, left ventricular ejection fraction.