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. 2012 Oct 25;1(5):e003434. doi: 10.1161/JAHA.112.003434

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© 2012 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley-Blackwell.

This is an Open Access article under the terms of the Creative Commons Attribution Noncommercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Figure 1. — Ex vivo retention of Cy5-labeled remnant lipoproteins and associated cholesterol in carotid arteries of the lean and MetS JCR:LA-cp rats after autologous perfusion (A through F). For autologous perfusion, MetS rat carotid vessels were perfused with remnants obtained from MetS rats, and lean carotid vessels were perfused with remnants obtained from lean rats. Representative images of the retention of Cy5-labeled remnants in carotid vessels of lean (A and C, ×10 magnification) and MetS (B and D, ×60 magnification) rats. Morphology of the vessel is shown in green and Cy5-labeled remnants in red. I indicates intima; M, media; AV, adventitia; and MetS, metabolic syndrome. Ex vivo retention of remnants in carotid vessels of lean and MetS rats was quantified further by measuring the fluorescent intensity in the linear range and calculating the corresponding number of apoB particles (using known concentration of apoB in the perfusate) (E) as well as the corresponding concentration of cholesterol (F), for each remnant preparation. *P<0.0001 (n=3, incorporating both carotids, 2 to 3 sections from each vessel, complete cross sections at ×10 magnification from each rat). (The unit on the y-axis in E and F also can be expressed as femtograms of apoB48). Images were collected in 3 dimensions for autologous perfusion (A through F for each arterial section).