Figure 9.

H₂S increases ischemic tissue XO activity that regulates ischemic tissue reperfusion and vascular remodeling. A and B, XO activity after H₂S therapy in wild‐type and eNOS^−/− mice 10 days after ligation. C and D, Blood flow recovery after febuxostat in wild‐type and eNOS^−/− mice in different time points. E and F, Angiogenesis index in wild‐type and eNOS^−/− mice 10 days after ligation. n=5 animals, per cohort, *P<0.05 compared to PBS ischemic tissue data and #P<0.05 compared to H₂S ischemic tissue data, or before and after ligation.