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. 2012 Oct 25;1(5):e004093. doi: 10.1161/JAHA.112.004093

Figure 12.

Figure 12.

H2S increases ischemic tissue VEGF expression that regulates reperfusion. A, Tissue concentrations of VEGF in ischemic and nonischemic tissues of 0.5 mg/kg sodium sulfide–treated animals at 7 days after ligation. B, Tissue concentrations of VEGF in ischemic and nonischemic tissues of sodium sulfide–treated animals at 10 days after ligation. C, Effect of H2S+cPTIO on VEGF expression in ischemic and nonischemic tissues. D, Concentrations of VEGF protein in tissues from H2S‐treated eNOS−/− mice in the presence and absence of L‐NAME or cPTIO. E, Ischemic limb blood flow values of wild‐type animals treated with H2S+VEGF164 aptamer or denatured VEGF164 aptamer. F, Tissue VEGF levels of wild‐type animals treated with H2S+VEGF164 aptamer or denatured VEGF164 aptamer. n=12 animals per experimental cohort, *P<0.05 compared to nonischemic, or VEGF164 aptamer data; #P<0.05 ischemic limb comparison, or before and after ligation.