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Blood lactate distribution over time. To show the efficacy of removal of lactate sequestered in tissue into central circulation, we determined lactate level at baseline, 5 minutes after initiation of cardiopulmonary resuscitation (CPR), and 5, 30, 60, 120, and 240 minutes after return of spontaneous circulation (ROSC). Peak of lactate appeared much earlier in the hands-on group, suggesting a more intensive reperfusion shortly after ROSC. Error bars show interquartile range.
