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. 2012 Dec 26;2012:708505. doi: 10.1155/2012/708505

Table 3.

Plasma concentrations of adipokines at baseline and 6 months. Statistical analysis was performed on 6 months log values. These means are estimated marginal means (SEM). Nontransformed values are presented for ease of reference.

Weight stable Weight loss 95% confidence interval
{cutoff for 50% power} 
for mean difference
(WL − WS) at 6 months
Men Women Men Women Men Women
(n = 12) (n = 13) (n = 12) (n = 14)
Log leptin, ng/mL
 Baseline 1.53 (0.08) 1.87 (0.08) 1.37 (0.09) 1.81 (0.08)
 6 months 1.37 (0.09) 1.88 (0.06) 1.30 (0.10) 1.74 (0.05) (−0.37, 0.20) (−0.31, 0.02)
{±0.29} {±0.17}
Leptin, ng/mL
 Baseline 39.72 (7.33) 86.53 (12.86) 26.54 (3.64) 77.16 (12.17)
 6 months 34.86 (7.16) 91.80 (12.71) 19.10 (2.14) 63.90 (12.69)

Log soluble leptin receptor, ng/mL
 Baseline 1.35 (0.02) 1.47 (0.04) 1.34 (0.02) 1.43 (0.04)
 6 months 1.31 (0.05) 1.53 (0.03) 1.40 (0.06) 1.49 (0.03) (−0.06, 0.25) (−0.14, 0.05)
{±0.16} {±0.10}
Soluble leptin receptor, ng/mL
 Baseline 22.70 (1.02) 30.44 (3.41) 22.10 (0.71) 28.68 (2.27)
 6 months 21.99 (1.86) 35.04 (2.68) 24.82 (1.36) 31.01 (2.08)

Log adiponectin, mg/mL
 Baseline 3.99 (0.06) 4.15 (0.06) 4.05 (0.07) 4.17 (0.05)
 6 months 4.02 (0.04) 4.12 (0.05) 4.04 (0.04) 4.25 (0.05) (−0.10, 0.14) (−0.03, 0.29)
{±0.12} {±0.16}
Adiponectin, mg/mL
 Baseline 11.41 (1.66) 15.08 (2.12) 12.13 (1.61) 16.60 (1.87)
 6 months 11.52 (1.51) 14.82 (1.67) 13.13 (1.90) 18.06 (1.70)

Log-free leptin index
 Baseline 2.18 (0.09) 2.41 (0.10) 2.02 (0.10) 2.38 (0.10)
 6 months 2.06 (0.12) 2.37 (0.06) 1.90 (0.13) 2.24 (0.05) (−0.53, 0.22) (−0.29, 0.04)
{±0.38} {±0.17}
Free leptin index
 Baseline 177.26 (33.67) 349.62 (75.91) 125.74 (18.89) 294.41 (51.15)
 6 months 276.27 (150.28) 272.86 (36.60) 76.45 (6.65) 213.85 (42.74)

Log leptin : adiponectin ratio
 Baseline 0.54 (0.11) 0.73 (0.10) 0.32 (0.12) 0.65 (0.10)
 6 months 0.37 (0.09) 0.78 (0.08) 0.24 (0.10) 0.48 (0.08) (−0.44, 0.17) (−0.54, −0.05)*
{±0.31} {±0.25}
Leptin : adiponectin ratio
 Baseline 4.12 (0.74) 7.53 (1.76) 2.82 (0.51) 5.42 (0.96)
 6 months 3.38 (0.64) 6.73 (0.91) 1.78 (0.30) 4.23 (1.05)

Log leptin/kg body fat
 Baseline −0.02 (0.07) 0.25 (0.08) −0.28 (0.08) 0.18 (0.08)
 6 months −0.16 (0.10) 0.24 (0.04) −0.30 (0.12) 0.21 (0.04) (−0.50, 0.21) (−0.16, 0.09)
{±0.36} {±0.13}
Leptin/kg body fat
 Baseline 0.97 (0.13) 2.06 (0.30) 0.69 (0.10) 1.77 (0.28)
 6 months 0.83 (0.14) 2.12 (0.29) 0.62 (0.07) 1.57 (0.20)

Free leptin index = (leptin : soluble leptin receptor) × 100.

*Indicates P < 0.050 for comparison between groups within gender. (Note that P < 0.050 corresponds to the associated difference confidence interval not overlapping 0.00.)

Indicates P ≥ 0.050 to <0.100 for comparison between groups within gender.

The power is 50% if the absolute value of the true mean difference equals the half width of the respective 95% confidence interval.