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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Cancer Res. 2012 May 2;72(13):3260–3269. doi: 10.1158/0008-5472.CAN-11-4141

Figure 3. Sustained PI3K inhibition decreases NF-κB activation by oncogenic PI3K mutations.

Figure 3

A) MCF10A cells stably expressing GFP, PIK3CA WT, E545K, or H1047R were starved for 24h, treated with 20μM LY294002 for 0–120 minutes and lysates were evaluated by immunoblot. B) MCF10A cells stably expressing GFP, PIK3CA WT, E545K, or H1047R were starved for 24h, treated with 20μM LY294002 for 0–10h and lysates were evaluated by immunoblot for the indicated signaling molecules.