Spatial learning in the Morris Water Maze. (A) Across 10 days, presented is the average (±SEM) latency (seconds) to locate the platform for wild type (WT), n=12, (dashed line) and cGKII knockout (KO), n=10 (solid line) animals. Days 1–5 of acquisition, the platform is hidden, Days 1–3 – Rev indicate latency to find the hidden platform during the reversal trials, and Days 1–2 – Vis indicate the latency to find the visible platform. (B) Presented is the average (±SEM) time spent in seconds during the probe trial in each quadrant for WT (white bar) and cGKII KO (black bar) animals. TQ = target quadrant, AR = adjacent right quadrant, OP = opposite quadrant, and AL = adjacent left quadrant. (C) Presented is the average (±SEM) number of platform crossings during the probe trial in WT (white bar) and cGKII KO animals (black bar).