Table 3. tk/ON/6213/66 (H5N1) is more virulent than tk/WI/68 (H5N9) by assay of survival of infected chicken embryos and mice.
Virus | Host | Dose (p.f.u.)* | LD50 | |||||
102 | 103 | 104 | 105 | 106 | 107 | |||
tk/ON/6213/66 (H5N1) | Chicken embryo | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | nd | <101.5 |
tk/WI/68 (H5N9) | Chicken embryo | nd | 4/4 | 4/4 | 4/4 | 4/4 | nd | >106.5 |
tk/ON/6213/66 (H5N1) | Mouse | nd | nd | nd | nd | 3/4 | 1/4 | 106.5 |
tk/WI/68 (H5N9) | Mouse | nd | nd | nd | nd | 4/4 | nd | >106.5 |
Survivors are indicated as the fraction of total mice or embryos infected with each dose.