Fig. 1.

Effects of adjuvant on the resulting immune response generated from PA+spore (BclA, ExsFA and p5303) vaccinations. (a) Changes in the anti-PA IgG titres of each vaccine group during the 12-week vaccination (pre-challenge) period. The vaccines were delivered at weeks 0, 4 and 8. Sera were collected just prior to each vaccine dose. (b, c) Spore antibody ELISAs using plates coated with Ames spores (b) or ΔbclA spores (c) and sera from mice collected at week 12 post-vaccination/pre-challenge. Representative data are shown. Sera collected from mice vaccinated with a prime and boost (2×) or a prime followed by two boosts (3×) were analysed.