Table 2. corna-based pathway analysis for early and late-exponential phase cultures of the S. uberis Vru mutant compared with S. uberis 0140J.

Pathway regulation in Vru mutant compared with wild-type strain	Pathway	Total genes involved in pathway	Expectation	Observation	Fisher distribution P value
Downregulated in early exponential growth phase	Sub00290; valine, leucine and isoleucine biosynthesis	7	2	7	0.013
Downregulated in early exponential growth phase	Sub00970; aminoacyl-tRNA biosynthesis	25	7	16	0.015
Upregulated in late-exponential growth phase	Sub00230; purine metabolism	47	13	28	<0.0002
Upregulated in late-exponential growth phase	Sub00061; fatty acid biosynthesis	12	3	11	<0.0002