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. Author manuscript; available in PMC: 2013 Dec 28.
Published in final edited form as: Open Immunol J. 2012 Dec 28;5:46–54. doi: 10.2174/1874226201205010046

Figure 5. Effect of inhalation of A. fumigatus conidia on IgA, IgG, and IgE antibody producing cells in the allergic mouse lung.

Figure 5

Mice were exposed to A. fumigatus according to the schedule shown in figure 1. Immunohistochemical staining was used to identify immunoglobulin producing cells in the lung tissue sections of day 0 (sensitized but not challenged with A. fumigatus) and day 5 allergic animals. IgA, IgG and IgE producing cells increased after allergen challenge with maximum numbers at day 5. (A, C, & E) Naïve BALB/c lungs had very few cells that localized Ig (IgA, IgG, and IgE). (B, D, & F) Day 5 BALB/c lungs contained substantial numbers of IgA, IgG, and IgE positive cells localized around the airways (indicated by arrows).