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. 2012 Oct;93(Pt 10):2183–2194. doi: 10.1099/vir.0.043711-0

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© 2012 SGM

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Fig. 5. — Schematic diagrams of the strategies used for construction of the four intergenotypic chimeric HEVs. (a) Two chimeric viruses were constructed using the genotype 1 human HEV infectious clone pSK-HEV-2 as the genomic backbone: chimera pSKHEV2-4h with the JR+ORF2+ORF3+3′NCR of genotype 4 human HEV replacing that of genotype 1 human HEV; and chimera pSKHEV2-3p with the JR+ORF2+ORF3+3′NCR of genotype 3 swine HEV replacing that of genotype 1 human HEV. (b) Chimera pHEV4TW-1h was constructed using the genotype 4 human HEV infectious clone pHEVTW-4 as the genomic backbone, with the JR+ORF2+ORF3+3′NCR of genotype 1 human HEV replacing that of genotype 4 human HEV. (c) Chimera pSHEV3-1h was constructed by using the genotype 3 swine HEV infectious clone pSHEV-3 as the genomic backbone, with the JR+ORF2+ORF3+3′NCR of genotype 1 human HEV replacing that of genotype 3 swine HEV.