Table 1. Replication competence in Huh7 cells and infectivity in HepG2/3A cells and in pigs of wild-type swine HEV genotype 3 and human HEV genotype 4, as well as intergenotypic chimeric HEV clones.

Inoculum	Replication competence in Huh7 cells	Infectivity in HepG2/3A cells	Infectivity in pigs
pSK-HEV-2 (genotype 1 human HEV)	+	+	−*
pSHEV-3 (genotype 3 swine HEV)	+	+	+
pHEV-4TW (genotype 4 human HEV)	+	+	+
Chimera pSKHEV2-4h	+	+	−
Chimera pSKHEV2-3p	+	−	−
Chimera pHEV4TW-1h	+	+	−
Chimera pSHEV3-1h	+	−	−†

^*The lack of infectivity in pigs of the genotype 1 human HEV was tested in a previous study (Meng et al., 1998a).

^†One pig inoculated with chimera pSHEV3-1h repeatedly tested positive for HEV RNA in bile collected during necropsy at 8 weeks p.i.