Table 4. Hazard Ratios (95% Risk limits) of Hip and Non-vertebral Fractures across PTH Quartiles.
| Model | N | Q1 | Q2 | Q3 | Q4 | p-trend |
|---|---|---|---|---|---|---|
| Hip Fractures | ||||||
| Base MV Model a | 2500 | 0.68 (0.35, 1.31) | 0.73 (0.38, 1.37) | 0.96 (0.52, 1.79) | Ref | 0.942 |
| Base MV Modela + Falls | 2425 | 0.65 (0.34, 1.27) | 0.72 (0.38, 1.35) | 0.90 (0.48, 1.68) | Ref | 0.798 |
| Base MV Modela + Health ABC Performance Score (0-4) | 2467 | 0.71 (0.36, 1.40) | 0.78 (0.41, 1.49) | 1.05 (0.56, 1.98) | Ref | 0.814 |
| Base MV Modela + IL-6 | 2476 | 0.69 (0.35, 1.36) | 0.73 (0.38, 1.39) | 0.91 (0.48, 1.73) | Ref | 0.810 |
| Base MV Modela + Serum Calcium | 2491 | 0.68 (0.35, 1.33) | 0.73 (0.39, 1.38) | 0.95 (0.51, 1.78) | Ref | 0.927 |
| Base MV Modela + Hip aBMD | 2479 | 0.84 (0.43, 1.64) | 0.86 (0.45, 1.64) | 1.03 (0.54, 1.95) | Ref | 0.930 |
| Base MV Modela + eGFR | 2500 | 0.68 (0.35, 1.32) | 0.73 (0.38, 1.38) | 0.96 (0.52, 1.80) | Ref | 0.956 |
| Base MV Modela + 25(OH)D | 2500 | 0.76 (0.38, 1.51) | 0.79 (0.41, 1.51) | 1.00 (0.54, 1.88) | Ref | 0.956 |
| Full MV Model (Base MV Modela + all mediators) | 2347 | 0.94 (0.44, 2.02) | 0.94 (0.47, 1.90) | 1.02 (0.51, 2.06) | Ref | 0.951 |
|
| ||||||
| Non-vertebral Fractures | ||||||
| Base MV Model a | 2500 | 0.99 (0.68, 1.42) | 0.85 (0.58, 1.23) | 0.95 (0.66, 1.36) | Ref | 0.588 |
| Base MV Modela + Falls | 2425 | 1.00 (0.69, 1.44) | 0.85 (0.58, 1.23) | 0.94 (0.65, 1.35) | Ref | 0.534 |
| Base MV Modela + Health ABC Performance Score (0-4) | 2467 | 0.95 (0.66, 1.38) | 0.83 (0.57, 1.20) | 0.90 (0.63, 1.31) | Ref | 0.444 |
| Base MV Modela + IL-6 | 2476 | 1.01 (0.70, 1.47) | 0.87 (0.59, 1.26) | 0.96 (0.67, 1.39) | Ref | 0.644 |
| Base MV Modela + Serum Calcium | 2491 | 1.00 (0.69, 1.45) | 0.86 (0.59, 1.24) | 0.96 (0.67, 1.39) | Ref | 0.641 |
| Base MV Modela + Hip aBMD | 2479 | 1.17 (0.81, 1.71) | 1.00 (0.68, 1.46) | 1.05 (0.72, 1.52) | Ref | 0.980 |
| Base MV Modela + eGFR | 2500 | 1.01 (0.70, 1.46) | 0.90 (0.62, 1.31) | 0.98 (0.68, 1.41) | Ref | 0.782 |
| Base MV Modela + 25(OH)D | 2500 | 1.01 (0.69, 1.49) | 0.86 (0.59, 1.25) | 0.96 (0.67, 1.38) | Ref | 0.614 |
| Full MV Model (Base MV Modela + all mediators) | 2347 | 1.29 (0.85, 1.94) | 1.11 (0.74, 1.66) | 1.07 (0.72, 1.58) | Ref | 0.944 |
*
Quartile cut points are 25.17 pg/ml, 33.81 pg/ml and 45.92 pg/ml
a
Base MV (multivariate) model adjusted for Age, Gender, Race, Season of blood draw, BMI, Current drinking, Fracture after age 45 and Clinical comorbidity index.