Table 3.
Patient ID | Ag expression on tumor (peptide HLA restriction) | Biomarker characterization | |||||||
---|---|---|---|---|---|---|---|---|---|
HLA type | AIM2 (A1) | gp100 (A1) | MAGE (A2) | TRP-2 (A2) | HER2 (A2) | ILRa2 (A2) | MGMT | PTEN | |
2 | A2+ | + | + | + | + | + | + | UnMet | RETAINED |
4 | A1+ | + | + | + | + | + | + | UnMet | N/A |
6 | A2+ | + | + | Wk | + | + | + | Met | RETAINED |
7 | A2+ | + | + | + | + | + | + | Met | LOSS |
9 | A2+ | + | + | − | + | − | + | Met | RETAINED |
10 | A2+ | + | + | Wk | + | + | + | INV | RETAINED |
11 | A2+ | + | + | + | + | + | + | UnMet | LOSS |
12 | A2+ | + | + | Wk | + | + | + | UnMet | RETAINED |
13 | A1+ | + | Wk | Wk | + | + | + | NT | LOSS |
14 | A1+ | + | + | − | + | + | + | NT | LOSS |
15 | A1+ | + | − | + | + | + | + | INV | RETAINED |
16 | A1 + A2+ | + | + | Wk | + | + | + | Met | LOSS |
17 | A2+ | + | − | Wk | − | + | − | NT | LOSS |
18 | A1+ | + | Wk | Wk | + | + | + | NT | LOSS |
19 | A2+ | + | + | Wk | + | + | + | Met | RETAINED |
20 | A2+ | + | + | Wk | + | + | + | Met | RETAINED |
Positive (+), negative (−), weak (Wk)
UnMet unmethylated, Met methylated, INV invalid results, NT not tested