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. 2001 Jul 3;98(14):7789–7794. doi: 10.1073/pnas.141222298

Figure 1.

Figure 1

Structural features of MusTRD1/BEN. (A) The relative localization of the six repeat domains in human TFII-I (hTFII-I, 957 aa) and the five or six repeat domains in MusTRD1/BEN (hMusTRD1, 944aa) and its isoforms (mGTF2IRD1a, 942 aa; hGTF3, 959 aa; mBEN, 1,072 aa; mGTF2IRD1b, 1,104 aa) is indicated. Although there is only 30–32% identity with TFII-I throughout the entire protein, the total homology among the repeats is 39%. (B) Ectopically expressed GST-TFII-I or GST-MusTRD1/BEN in COS7 cells was visualized by anti-GST antibody. The percentage subcellular distribution of each protein is indicated at the bottom. (C) Endogenous nuclear expression of MusTRD1/BEN in HeLa cells was visualized with the use of an affinity-purified rabbit polyclonal anti-BEN antibody.