Table 2.
Effects of intermittent ethanol and MDMA administration during adolescence on the concentration of brain monoamines in the striatum and hippocampus in mice
| Sal | M10 | M20 | E1.25 | E1.25+M10 | E1.25+M20 | |
|---|---|---|---|---|---|---|
|
Striatum | ||||||
|
DA |
12364±1015 |
13315±981 |
7454±713*** |
11962±1176 |
9471±1929*** |
9850±1041*** |
|
DOPAC |
1519±210 |
927±102 |
719±53++ |
1082±119 |
1069±202 |
765±106++ |
|
DATurnover |
0.12±0.02 |
0.07±0.001** |
0.1±0.01 |
0.09±0.01* |
0.11±0.01 |
0.08±0.001 |
|
5-HT |
924±76 |
1110±95 |
825±72 |
1247±98+ |
1128±167+ |
1200±289+ |
|
5-HIIA |
547±86 |
441±16 |
450±47 |
590±101 |
859±234 |
507±57 |
|
5-HT Turnover |
0.59±0.07 |
0.4±0.02 |
0.6±0.06 |
0.51±0.08 |
0.75±0.17 |
0.53±0.18 |
|
Hippocampus | ||||||
|
5--‐HT |
534±37 |
570±67 |
489±179 |
959±207+ |
560±48+ |
635±56+ |
| 5--‐HIIA | 504±85 | 613±111 | 541±65 | 1109±375 | 496±69 | 637±37 |
Animals were treated during adolescence with Saline (Sal), 10 mg/kg of MDMA (M10), 20 mg/kg of MDMA (M20), 1.25 mg/kg of ethanol (E1.25), 1.25 mg/kg of ethanol+10 mg/kg of MDMA (E1.25+M10), or 1.25 mg/kg of ethanol+20 mg/kg of MDMA (E1.25+M20). Data are presented in means with ±S.E.M. Differences with respect to the saline group *p< 0.05, ** p< 0.02, *** p< 0.001; differences with respect to non-EtOH treated groups + p< 0.03; differences with respect to non-MDMA treated groups ++ p< 0.001.