Table 1. Summary of the factors that may affect enterotyping.

	Strength	Effect	No effect
Known effects	Strong	Distance metric	Rarefaction
	Strong	Cluster scoring method
	Strong	Taxonomical level
	Moderate	Variable region of the 16S rRNA
	Weak	16S rRNA vs. WGS data
	Weak	OTU picking method
Potential effects to be tested		Sample processing method
		Batch effects
		PCR conditions
		Study size