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. 2013 Jan 10;9(1):e1003198. doi: 10.1371/journal.pgen.1003198

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© 2013 Thomas et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

Schematic diagram showing the organization of genes encoding HelP, ConQ and NicK in ICEBs1 and their homologues Orf23, Orf22, Orf21, and Orf20 in Tn916. Most (>40) of the 72 ICEs in the ICEberg database that have helP homologues have this consecutive (helP)-helP-conQ-nicK configuration. Some ICEs have the same gene order but have an additional one or two genes located between the helP and conQ and/or between conQ and nicK. Not shown is a different gene organization found in ICEs related to ICE6013 in which the conQ is separate from helP and nicK.