Table 5. Estimates of the sensitivity of rK39 RDTs to detect Leishmania infantum infection in dogs.

Country	Study design1	Supplier2	Reference test	Number of dogs	rK39 RDT % (95% CI)	ELISA4 %	IFAT %	Ref.
China	XS	Corixa	Smear	3	100 (43.9–100)	-	-	[13]
Brazil	XS	Intersep	PCR or ELISA	74	71.6 (60.5–80.6)	-	-	[14]
Mediterranean	CC	Diamed	Culture or PCR	47	80.9 (67.5–89.6)	100	68	[18]
Turkey	XS	Intersep	ELISA	15	86.7 (62.1–96.3)	-	100	[20]
Iran	XS	Cypress	DAT	26	38.5 (22.4–57.5)	-	-	[21]
Brazil	CC	Inbios	Smear	76	82.9 (72.9–89.7)	95	-	[22]
Argentina	XS	Inbios	PCR	51	64.7 (51.0–76.4)	-	65.4	[25]
Brazil	XS3	Inbios	IFAT	23	13.0 (4.5–32.1)	-	-	[27]
China	XS	Inbios	PCR or ELISA	62	14.5 (7.8–25.3)	59	-	[28]
Brazil	Cohort	Inbios	PCR or ELISA	54	46.3 (33.7–59.4)	85	-	this study
Combined					59.3 (37.9–77.6)

¹CC – case-control; XS – cross-sectional;

²Inbios International Inc, WA, USA; Corixa, USA; Cypress Diagnostic Company, Belgium; Intersep DiaSys Europe Ltd; Diamed AG, Switzerland;

³data from first time-point of a cohort study;

⁴crude antigen.