Figure 1. Radiographic findings in patient 1. (A) An initial CT-scan of the chest showed a large tumor arising from the left lower lobe of the lung. (B) An initial staging PET CT-scan showed diffuse FDG avidity suggestive of widespread metastases involving the skeleton. (C) After 6 mo of Crizotinib monotherapy, the patient had a partial response with remarkable improvement in Fluorodeoxyglucose (FDG) avidity seen in a PET CT-scan. (D) An MRI of the brain at 6 mo showed development of 12 brain metastases, two of which are visible in this axial T1-post contrast image.