Table 1. The clinicopathologic features of three patients with EML4-ALK translocation positive NSCLC are summarized that developed progressive brain metastases in spite of good systemic control elsewhere.

Patient	Age at diagnosis	Histopathology	Primary tumor	Sites of Disease at diagnosis	Sites of disease progression	No. of CNS lesions	Smoking status	Brain RT
1	41 y	Moderately-differentiated adenocarcinoma	Left lower lobe	Skeleton	Brain	12	Never smoker	SRS 20 Gy
				Bilateral lungs
				Mediastinum
2	51 y	Moderately-differentiated adenocarcinoma	Right middle lobe	Brain	Brain	36	Never smoker	SRS 15 Gy
				Skeleton
				Mediastinum				WBRT 37.5 Gy
3	59 y	Moderately-differentiated adenocarcinoma	Right hilum	Brain	Brain	22	Never smoker	WBRT 35 Gy
				Supraclavicular
				Bilateral Pleural Efusion
				Mediastinum

CNS, central nervous system; SRS, stereotactic radiosurgery; RT, radiation therapy; No., number; WBRT, whole brain radiotherapy; Gy, Grey (joule per kilogram).