Figure 6. Growth kinetics of HT-29-xenografted tumors (A). HT-29 cells were injected subcutaneously into each flank CD1 athimic nude mice. Mice were treated daily with SB202190 or sorafenib or a combination of both or the vehicle alone starting when tumors had reached a mean volume of 100 mm³. Animals were sacrificed when control tumors reached a mean volume of around 550 mm³. Representative tumors explanted from mice after the indicated treatments (B). Graph showing the volume of explanted tumors (mean ± SD) (C).