Figure 8. OSU-03012 and lapatinib interact in vivo to suppress tumor growth. DAOY cells (1 × 10⁷) were injected into the rear flanks of athymic mice. Tumors formed over the following month (~200 mm³, per treatment group, day 0). Animals were doses with drugs: vehicle (DMSO and Cremophore); Lapatinib (100 mg/kg, BID); OSU-03012 (25 mg/kg QD) or both drugs combined. Tumor volumes were assessed by caliper on the indicated days (n = 2 experiments with 3 animals per group in each experiment: total 6 animals per group ± SEM). * p < 0.05 less than other treatment values.