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. 2012 Dec 28;12:627. doi: 10.1186/1471-2407-12-627

Table 4.

Reports of miR-200 in ovarian cancer

miRNA Findings Reference
200a/b/c
High expression in ovarian cancer samples
[7,8,10]
 
High expression correlated with decreased progression-free survival
[8]
 
Decreased in tumors with high β-tubulin III levels
[33]
200a
Increased in 43% of primary ovarian carcinomas, associated with high-grade and late-stage tumors
[9]
 
High expression correlated with recurrence free survival and, or, overall survival
[34,35]
 
Increased tumour growth, targets p38α and modulates oxidative stress signature
[34]
 
Sensitized tumors to paclitaxel
[34]
200c
Targeted TUBB3 for degradation leading to increased paclitaxel sensitivity
[36]
 
Low levels associated with incomplete response to paclitaxel–carboplatin chemotherapy and recurrence
[33]
 
Decreased adhesion to basement membrane complex
[36]
  Repressed ZEB1, decreased migration and invasion in HEY cells [36]