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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Nat Biotechnol. 2012 Dec 16;31(1):63–70. doi: 10.1038/nbt.2464

Figure 2. Urinary detection of in vivo protease activity with peptide-NWs.

Figure 2

(a) Shown are representative activation profiles of peptide-NWs following treatment with recombinant proteases. Specific protease-substrate combinations led to rapid increases in sample fluorescence. (b) Heat map comparison of cleavage velocities for different substrate-protease combinations grouped according to activity and specificity. (c) Fluorescence in vivo images of DDC-treated and control animals following intravenous injection of VivoTag-680 labeled Glu-fib peptides, (d) peptide-free NWs or (e) peptide-conjugated NWs.