Table III.
Expression of IL-17A gene in PBMC, its plasma concentration and cutaneous expression in the study and control groups
| Variables | Morphea | MEP | GM | LM | Control | |
|---|---|---|---|---|---|---|
| Expression in PBMC (per million copies of GAPDH) | n | 41 | 20 | 14 | 7 | 47 |
| Median | 2630 | 2923 | 2524 | 2435 | 1906 | |
| Min. | 1134 | 1161 | 1134 | 1524 | 702 | |
| Max. | 10896 | 10896 | 4706 | 3109 | 7540 | |
| p | 0.004* | 0.004* | 0.162 | 0.172 | – | |
| Plasma concentration [pg/ml] | n | 41 | 20 | 14 | 7 | 47 |
| Median | 10 | 10 | 10 | 11 | 10 | |
| Min. | 0.0 | 0.0 | 8 | 6 | 4 | |
| Max. | 40 | 25 | 40 | 18 | 104 | |
| p | 0.639 | 0.638 | 0.945 | 0.579 | – | |
| Expression in skin (per million copies of GAPDH) | n | 29 | 13 | 10 | 6 | 13 |
| Median | 9116 | 12743 | 9976 | 6816 | 19113 | |
| Min. | 0.0 | 2149 | 0.0 | 2200 | 6907 | |
| Max. | 2899083 | 79534 | 2899083 | 39256 | 223284 | |
| p | 0.036* | 0.151 | 0.162 | 0.025* | – |
PBMC – peripheral blood mononuclear cells, n – number of patients, p – value of p related to the control group, other abbreviations – see Table II
*
significant difference