Figure 2.

Anti-Hebbian STDP in a cerebellum-like structure. (A) Temporal order for the induction of LTP and LTD at parallel fiber synapses onto Purkinje-like cells in the electrosensory lobe of the mormyrid fish Gnathonemus petersii. Changes in EPSP amplitudes are plotted against the delay between EPSP onset and the broad spike peak during the pairing period (360 stimuli at 1 Hz). (B) Model scheme for anti-Hebbian STDP. LTP is induced when the spike is initiated before an EPSP is evoked. Stimulation in the reverse order (EPSP-spike) results in LTD. Note that this figure panel shows an idealized model of anti-Hebbian STDP and differs from the experimentally obtained data presented in (A), in which potentiation is also seen with intervals >400 ms. (A) is modified from Bell et al. (1997) with permission from Macmillan Publishers Ltd: Nature, copyright 1997.