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. 2012 Dec 4;8:629. doi: 10.1038/msb.2012.59

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Copyright © 2012, EMBO and Macmillan Publishers Limited

This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial Share Alike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission.

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Protein network analysis of hits reveals multiple connections between signaling molecules and Golgi proteins. (A) A map of 111 hit kinases on the phylogenetic tree of kinases. (B) Step-wise construction of the Golgi regulatory network. In all, 413 of the 854 proteins localized at the Golgi in the GO database are also found in the Phosphosite plus database. A functional filter using Biological Process GO yields 135 phosphorylated proteins present at the Golgi and functioning in membrane trafficking. Using protein–protein interaction information from 3 databases (String, Pathway Studio and HPRD), 37 of these Golgi Proteins were reported to have a direct interaction with 86 hits. (C) A preliminary map of the Golgi regulatory network arranged based on available Cellular Compartment GO for all 123 genes.