Figure 5.

The NNF structure oscillates over the widest range of parameters. (A) The transcription rate of the repressor and the activator are changed from their initial value, and the range of parameters where the rhythms persist is shown. Here, dissociation constant, K_d=10⁻⁵ and clearance rate of activator, δ=0.2. When K_d is varied, the NNF model still has the widest range of parameters (Supplementary Figure 5C). When δ increases, the range of parameters that generate the sustained rhythms decreases (Supplementary Figure 5D). (B) Repeats the tests with the detailed mammalian model and (C) uses a Drosophila model. Details about these plots, as well as our methods for generating them are described in Supplementary Figure 5A–C.