Table 2. Comparison of modified model predictions with experimental data of single SCN neurons on the phenotypes of circadian mutations.
Gene | dSCN | Model |
---|---|---|
Cry1 −/− | AR | AR |
Cry2 −/− | Long | +2.3 |
Per1 −/− | AR | |
Per1 ldc | AR | |
Bmal1 −/− | AR* | AR |
Here, we indicate whether the phenotype predicted by our model, or seen in experimental data is arrhythmic (AR) or shows a change in period in hours. Experimental data can be found in Liu et al (2007), except those marked with * which can be found in Ko et al (2010). See Materials and methods for details.