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Surface plasmon resonance for compound 14 with Tdp1. The binding of compound 14 to Tdp1 was examined using SPR spectroscopy. Different concentrations of 14 (50, 25, 12.5 and 6.25 μM) were injected over immobilized Tdp1. The kinetics were fit to a 1:1 binding model yielding the following parameters, ka 7.7e4 1/Ms, kd 0.24 1/s and KD 31 μM.
