Table 3.
Summary of Nonsynonymous SNPs and Small Indels
| Household/isolate | Gene | COG | Mutation |
|---|---|---|---|
| HH1000/1005 | ileS | J | I473N |
| Zinc protease | R | P52S | |
| Nicotinate phosphoribosyl transferase | H | G340A | |
| sdrC | None | Δ75 bp SD region | |
| HH1000/1003 | spa | JM | E393A, Δ24 bp |
| gid | J | A133V | |
| Nramp | P | Y304F | |
| HH2000/2002 | CDP-ribitol-phosphotransferase | M | S400N |
| lacC | G | W218a | |
| moeA | H | M25I | |
| hlgA | None | D130E | |
| hlgC | None | L2I, L79F, L126F | |
| Conserved hypothetical protein | None | 9 bp insertion | |
| HH1000 and HH2000 combined, “Persisting strains” | gyrA | L | L84S |
| tRNA-Arg | S | E17D | |
| Hypothetical membrane-span protein | S | D71N | |
| parC | L | Y80S | |
| O2-independ.coprophyrinogen-oxidase | H | T145A | |
| Transaldolase | G | I6V | |
| Transporter, MMPL family | R | K795Q | |
| HH3000/3001, “Non-persister” | Cytosolic protein | C | G26D |
| yqiG | C | A219E | |
| Cell division protein ftsH | O | D336G | |
| Hypothetical membrane-span protein | S | P220L | |
| Transcriptional regulator, MarR | K | W48a | |
| Hypothetical membrane-span protein | TK | W199R | |
| Arogenate dehydrogenase | E | G336V, Y335a | |
| Erythrocyte membrane-span protein | LVDSRM | T8428S | |
| proC | E | D152N | |
| kipl | E | E60G | |
| rpmA | J | Y54H | |
| icaA | Δ5 bp (239a) | ||
| lukE | None | Δ1 bp (6a) | |
| Hypothetical cytosolic protein | J | N721K |
aMissense mutation.