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. 2012 Sep 18;10:105. doi: 10.1186/1741-7015-10-105

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Copyright ©2012 Liu et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Pinocembrin inhibited mitochondrion-induced apoptosis. (A) Fluorescent images of B cell lymphoma 2 (Bcl-2), cytochrome c and nucleus in the same field. (B,C) Values of Mean_AvgInten of Bcl-2 and cytochrome c collected from the respective fluorescent channels using the same optical field. Data are expressed as mean ± SEM, n = 6, ***P < 0.001 vs control, ^##P < 0.01, ^###P < 0.001 vs copper. (D) Activity of caspase 3 and caspase 9 of human neuroblastoma SH-SY5Y cells overexpressing the Swedish mutant form of human APP (APPsw) in the presence of copper. Data are expressed as mean ± SEM, n = 4, ***P < 0.001 vs control, ^##P < 0.01, ^###P < 0.001 vs copper.