Table 3. Relative expression of functional gene cluster before and after NOX4 antibody (Ab), ascorbic acid, and ascorbic acid/NOX4 Ab infusion in injured spinal cord tissue.
Description | Normal |
Fold change (P-value) |
|||
---|---|---|---|---|---|
ScramRNA/pain | NOX4 Ab/pain | Ascorbic acid/pain | Ascorbic acid/NOX4 Ab/pain | ||
Immunomodulatory factors | |||||
TGFβ1 | 1.00 | 0.78 | 1.88 (P<0.01) | 1.03 (NS) | 1.38 (P<0.01) |
TGFβ2 | 0.52 | 1.45 (P<0.01) | 0.73 (NS) | 1.08 (P<0.05) | |
IL-10 | 0.46 | 0.94 (P<0.05) | 0.72 (NS) | 0.90 (P<0.05) | |
Inflammatory cytokines | |||||
IL-1β | 1.00 | 2.86 | 1.84 (P<0.05) | 2.48 (NS) | 1.94 (P<0.05) |
Redox scavengers | |||||
GPX1 | 1.00 | 1.12 | 1.06 (NS) | 1.12 (NS) | 1.11 (NS) |
GPX3 | 0.66 | 0.92 (P<0.05) | 0.94 (P<0.05) | 1.04 (P<0.01) | |
TXNL1 | 0.24 | 1.06 (P<0.05) | 0.85 (P<0.05) | 1.18 (P<0.05) | |
GAPDH | 1.03 | 0.96 (NS) | 1.04 (NS) | 1.08 (NS) |