Figure 6.

Nec-1s does not show a paradoxical dose response in TNF-induced SIRS. (a) TNF shock-associated hypothermia. Nec-1 and Nec-1s were injected i.v. at a dose of Hi: 6 mg/kg b.w. or Lo: 0.6 mg/kg b.w. 17 min before the challenge with mTNF; i.v. Nec-1s was as protective as Nec-1 but lacked the sensitizing effect of Nec-1 at the lower dose. (b) Survival curve for the experiment described in a. Symbols of Nec-1 Hi and Nec-1s Hi coincide and are both completely protective. A cumulative result of two independent experiments is represented. Number of mice is indicated between brackets. ^*P<0.05, ^**P<0.001 and ^***P<0.0001