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Effect of VE-822 on 53BP1, γH2AX and Rad51 foci formation. (a and b) VE-822 (80 nM) was added to cells 1 h before XRT with 6 Gy. Cells were fixed at 24 h post-XRT, stained for γH2AX and 53BP1 foci and the percentage of cells with more than 7 and 5 foci per cell was quantitated, respectively. (c) The percentage of cells with more than 9 Rad51 foci per cell was quantitated at 6 h post-XRT. Representative images are shown on the right (means±S.D.; n=3). *P<0.05; **P<0.01
