Table 1. Concentrations of serum immunoglobulins and free light chains in normal subjects and 339 patients with multiple myeloma, showing median values together with (95% ranges).
| Normals | IgGκ myeloma (n=166) | IgGλ myeloma (n=79) | IgAκ myeloma (n=60) | IgAλ myeloma (n=34) | |
|---|---|---|---|---|---|
| Monoclonal Ig by SPEP (g/l) | Not applicable | 40.5 (8.0–90) | 46.0 (10.9–85) | 34.0 (11.4–89) | 28.0 (3.46–62) |
| Total IgG (g/l) | 10.9a (7.05–17.45) | 45.7 (12.5–105) | 53.8 (6.21–104) | 3.43 (0.85–8.78) | 3.9 (1.53–7.83) |
| IgGκ (g/l) | 6.82b (4.01–9.77) | 33 (5.6–92) | 0.41 (0.12–5.84) | Not recorded | Not recorded |
| IgGλ (g/l) | 3.83b (1.98–5.71) | 0.33 (0.072–2.03) | 35.5 (4.8–91) | Not recorded | Not recorded |
| IgGκ/IgGλ ratio | 1.87b (1.09–2.60) | 93.5 (5.13–864) | 0.018 (0.001–0.878) | Not recorded | Not recorded |
| Total IgA (g/l) | 2.39a (0.87–5.76) | 0.31 (0.06–2.61) | 0.28 (0.07–2.33) | 39.3 (9.6–107.6) | 32.8 (1.8–65.5) |
| IgAκ (g/l) | 1.19c (0.47–2.82) | Not recorded | Not recorded | 36.7 (5.36–110) | 0.3 (0.018–2.17) |
| IgAλ (g/l) | 0.98c (0.36–1.98) | Not recorded | Not recorded | 0.072 (0.017–1.13) | 30.1 (1.95–50) |
| IgAκ/IgAλ ratio | 1.27c (0.80–2.04) | Not recorded | Not recorded | 462 (11.2–6020) | 0.01 (0.018–0.255) |
| Total IgM (g/l) | 1.34a (0.46–3.86) | 0.22 (0.04–1.61) | 0.21 (0.037–0.93) | 0.18 (0.04–0.66) | 0.21 (0.056–8.77) |
| FLC-κ (mg/l) | 7.30d (3.3–19.4) | 175 (9.66–5645) | 7.14 (0.40–37.9) | 183 (7.99–12 165) | 6.53 (1.27–36.1) |
| FLC-λ (mg/l) | 12.40d (5.7–26.3) | 5.43 (0.50–17.0) | 315 (9.62–7015) | 2.24 (0.18–143) | 220 (17.4–22 683) |
| FLC ratio | 0.60d (0.31–1.2) | 60.1 (1.8–2237) | 0.02 (0.0–1.05) | 68.7 (0.98–10 298) | 0.02 (0.0001–0.56) |