Table 1. Human myeloid progenitor quantification in mouse BM at 8 weeks post-transplantation.
| Cells infused | Mouse No | GFP | Patient No |
CFCs/104
CD45+
cells in mouse BM |
B/A+ CFCs/total CFCs | |||
|---|---|---|---|---|---|---|---|---|
| BFU-E | CFU-GM | CFU-GEMM | Total | |||||
| Control GFP | 17 | − | 1 | 28 | 40 | <1 | 68 | 13/13 |
| + | 1 | 6 | <1 | 7 | ND | |||
| 18 | − | 2 | 1 | 4 | <1 | 6 | ND | |
| + | <1 | 3 | <1 | 3 | ND | |||
| NA10HD | 12 | − | 2 | 2 | 19 | <1 | 21 | 0/14 |
| + | 125 | 84 | 1 | 210 | 6/16 | |||
| 15 | − | 1 | 46 | 79 | <1 | 125 | ND | |
| + | <1 | 2 | <1 | 2 | ND | |||
| 20 | − | 2 | 5 | 10 | <1 | 15 | 0/14 | |
| + | 139 | 117 | <1 | 256 | 12/13 | |||
| 24 | − | 2 | 1 | 2 | <1 | 3 | ND | |
| + | 192 | 137 | 3 | 333 | 8/8 | |||
Abbreviations: B/A+, BCR-ABL+; BM, bone marrow; CFC, colony-forming cell; GEMM, granulopoietic, erythroid and multi-potent myeloid; GFP, green fluroscent protein; GM, granulopoietic; ND, not done.