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Proposed models for the membrane-spanning sequences of HIV gp41. The two models for the HIV gp41 MSD are shown schematically using the sequence from HIV-1 89.6. (Left) The traditional model, with the MSD as a single α-helix. (Right) The alternative model proposed by Hollier & Dimmock (2005) with three membrane-spanning β-sheets. Residues are numbered according to the standard HXB2 sequence, and residues 706–746 are left out for simplicity.
